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This book brings together a range of academic, industry and practitioner perspectives on translational medicine TM. It enhances conceptual and practical understanding of the emergence and progress of the field and its potential impact on basic research, therapeutic development, and institutional infrastructure. In recognition of the various implications TM has for public health policy and commercial innovation, the book addresses the major systemic aspects of the field. The contributors explore the dynamic interactions and key challenges in translating new science into viable therapies for the clinic, which includes recognizing the importance of social, commercial, and regulatory environments in addition to good science.

Unlike other contributions in the field, it takes a holistic approach to the problem and recognises the dynamic nature of demand for as well as supply of health innovation, identifying strategies to integrate the two. This book has been needed for some time, but, with stagnating productivity and ever-increasing economic pressures, never more so than right now.

Future of translational research: Why go pragmatic?

New Light Through an Old Window? His research and teaching focuses on interdisciplinary approaches to the complex and dynamic ways in which life sciences are affecting the nature and the process of technological and therapeutic innovation within the pharmaceutical and biotechnology sectors. American Society of Clinical Oncology. American Association for Cancer Research. HK conceived of the study, and participated in its design and coordination and helped to draft the manuscript. DB conceived of the study, and participated in its design and coordination and helped to draft the manuscript.

CJR conceived of the study, and participated in its design and coordination and helped to draft the manuscript.

References

All authors read and approved the final manuscript. Data sharing not applicable to this article as no datasets were generated or analyzed during the current study. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.


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Table of Contents Abstract Declarations References. Commentary Open Access.

Translational research as prerequisite for personalized psychiatry | SpringerLink

On the brink of extinction: the future of translational physician-scientists in the United States. Journal of Translational Medicine 15 Abstract Over the past decade, we have seen an unparalleled growth in our knowledge of cancer biology and the translation of this biology into a new generation of therapeutic tools that are changing cancer treatment outcomes.

Early career physician-scientists, specifically physician-scientists, appear to be the most vulnerable. A review of funded early physician-scientist Grants e. The decline in early career physician-scientist funding coincides with the Great Recession of In the economic recovery that has followed from to the present, NIH has not reinstated physician-scientist funding to previous levels.

Fewer physician-scientist grants are being submitted to NCI. Acknowledgements Not applicable. Competing interests The authors declare that they have no competing interests. Availability of data and materials Data sharing not applicable to this article as no datasets were generated or analyzed during the current study.

Paradoxically, restoring the blood supply to the heart leads to more damage, termed reperfusion injury. In the past, preconditioning techniques were developed that would prevent reperfusion injury, but their translation into the clinic is limited as they require prior knowledge of a cardiac ischemic event. Babiker advocates the use of a technique that may have practical clinical application in that it can be implemented post-ischemically, such as after a heart attack.

He describes the technique of pacing post-conditioning which involves subjecting the post-ischemic heart to brief episodes of mechanical dyssynchrony that can be induced by ventricular pacing at a normal heart rate during the very early phase of reperfusion to afford cardioprotection. The practical utility of this technique has been studied in a recent clinical trial by one of Dr. Babiker's previous laboratories, and the results appear promising for the translation of this technique into the clinic.

Indeed, recent advances by his own group in understanding the underlying mechanisms by which pacing post-conditioning affords cardioprotection and the possible use of pharmacological agents to mimic pacing post-conditioning might lead to further clinical trials and applications. Finally, Lakha et al. Chronic pain is universally debilitating, but its management can vary significantly depending on patient demographics and geography. The authors review the delivery of services for the management of chronic pain in Kuwait and identify the barriers to this delivery of services and patient compliance.

They suggest the need for a holistic approach for the general well-being of the patient rather than focusing on the symptoms of pain alone. Furthermore, based on their findings, the authors have compiled a plan for improving integrative chronic pain management in Kuwait.


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If implemented, this would represent a significant step forward in translating basic biomedical research into bedside clinical practice. In conclusion, we would like to thank all the authors for their important contributions that highlight the need for translational medicine in improving future health care in Kuwait and beyond. After all, this is the essence of translational medicine. Distribution permitted for non-commercial purposes only. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication.

However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor s.