To be more explicit, it is possible that [the Roman kings] reigned not by right of birth, but in virtue of their divinity as representatives or embodiments of a god, and that as such they mated with a goddess…. Eingeordnet unter Gedanken , Mythologie. Sign me up! Zum Inhalt springen.
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Startseite About Hinweis. You see, the real value of a conflict, the true value, is in the debt that it creates. You control the debt, you control everything. You find this upsetting, yes? But this is the very essence of the banking industry, to make us all, whether we be nations or individuals, slaves to debt. Ihr Ziel ist es, nicht den Konflikt zu kontrollieren, sondern vielmehr die Schulden zu kontrollieren, die der Konflikt erschafft.
Sie muessen wissen, der reale Wert eines Konfliktes, der wahre Wert, liegt in der Schuldenkontrolle. Wenn sie die Schulden kontrollieren, kontrollieren sie alles. Sie finden das verstoerend?
Aber es ist der wahre Kern der Bankwirtschaft, uns alle, egal ob als Nation oder als Individuum, zu Sklaven der Schulden zu machen…. In 20 years of experiencing and 10 years of living in Ireland to this day I am always caught by these random acts of kindness. Somebody walks up to you and does something completely unexcpected and real nice. These people can be acquaintances but preferrably they are strangers we all are strangers almost everywhere…. For example 20 years ago I was somewhere in Ireland trying to hitchhiking home. As it was getting late afternoon that day and I didnt have money to stay somewhere I decided to take a bus.
Anyways, some 50 yards up the road an old lady came out the house and walked to the busstop. She told me the next bus would be another hour away and invited me to her house for a cup of tea in they didnt have these fancy coffees — and cappucino was a horse…. Would you let any stranger who was also very skinny and looked very hungry into your house? She gave me towel so i could dry my hair and we had the loviliest conversation ever.
Dont ask me what we were talking about, or what her name was or where in Ireland it was. But I will never forget this cup of tea and sandwiches she made for me. And I also remember the feeling I had when the bus arrived we nearly had missed it, but the driver was waiting when she signalled hin to wait form the porch and I was sitting then on the bus — warm, dry and well fed. And at that time I had not given myself the time of the day. It was the best ever. Followed closely by the second of the Ten Best of Random acts. When I arrived in Galway in November of Being very hungry and no money in my pocket again I arrived with the bus it really was a luxury to afford a lift when you have no money at all and was walking with a man who I had a brief conversation with on the bus across Eyre Square.
He then invited me to an early lunch I must have looked really really hungry. Just like that. Whenever I am seriously fed up with the home of my choice these things happen. I dont know any other place in the world where you have this. It can happen everywhere but in Ireland its part of the lifestyle.
And you do it to other people as well. No big deal. But it certainly makes your day. Not because you are great. F… that. No, its the randomness of it all. Or as the Irish would say:. Be always nice to a stranger, he could be a friend. Sadly the Irish losing it a bit.
And in the UB40 Song is all actual again: Money is too tight to mention… No, for oldstyle — go to the south of wales. Not that developed, not that efficient. Quality of life — the essential bit the irish lost when they started dancing around the golden calf…. Hinterlasse einen Kommentar Eingeordnet unter Gedanken , Irland. Hinterlasse einen Kommentar Eingeordnet unter Gedanken , Politik.
Meine persoenliche Cornwall Option ist gerade ruhmlos zu Grabe getragen worden. Ich moechte gleich eingangz erklaeren, dass ich die britischen Inseln als ganzes nicht nur faszinierend finde wuerde ich ansonsten seit ueber 11 Jahren hier leben? Selbst Yorkshire men and women…. Ob ihrer Schrulligkeit mildly excentric und ihrer Liebe zu Traditionen und allem was alt ist. Und in vielem der deutschen Mentalitaet nicht unaehnlich.
Jedenfalls den Teil den ich mag. Eigentlich sind sich Grossbritannien und Deutschland mehr als nur aehnlich, aber dazu spaeter mehr. Jedenfalls ueberlege ich seit knapp 2 Jahren, wenn meine Zeit in Irland vorbei ist, nach Cornwall zu gehen. Im Herzen sind die Cornwallis keine Englaender, sondern das bisschen mehr schrullig und ein bisschen wie die Iren. Aber sowohl Sprache wie auch kulturelle Identitaet bei weitem nicht so stark ausgepraegt wie in Wales oder Schottland.
Wie dem auch sei, ich habe mich vorhin mit einer deutschen Frau unterhalten, und die hat mir folgendes erzaehlt: als sie im Februar von Irland nach England geflogen ist, haben die ihren Personalausweis gescannt sie meinte, zum Glueck hatte ich nicht meinen neuen Reisepasse mit den Fingerabdruecken dabei. Das beste war aber auf dem Weg zurueck: da haben sie sie fotografiert und meinten, dass das Bild nach 24 Stunden geloescht werde wuerde. Urlaub ja — Leben nein. Grossbritannien ist bekannt, dass die schon unter Thatcher angefangen haben, tausende von Ueberwachungskameras zu installieren — und sind allen europaeischen Staaten in bezug auf flaechendeckende Kontrolle der Bevoelkerung um Jahre voraus.
Aber das wird noch kommen…. Nun, hier die Sieben Gebote, die Tiere erlassen, als ihr menschlicher Unterdruecker stirbt:. Alle Tiere sind gleich, Aber manche sind gleicher. Die Leser koennen denken was sie wollen, aber Orwell hatte schon eine ziemliche Weitsicht die meiner Ansicht nach die von Churchill uebertrifft, und der war schon gut — in seinem Wahn. Und wir bewegen uns in immer offensichtlicher nicht mehr haeppchenweise oder Stueckchen fuer Stueckchen sondern mit Siebenmeilenschritten um bei den Maerchen metaphern zu bleiben…; diesen duesteren Visionen entgegen.
Wer haette je gedacht, dass der postmoderne Faschismus nicht nur den besten Naehrboden in Grossbritannien gefunden hat dont be fooled, the others are following , sondern er wird auch hier zu seiner Bluete kommen. Mit London, einem Stadtteil des neuen Babylon, als europaeischem Hauptsitz Bruessel ist einfach zu haesslich. Ist doch komisch, bin schon haeufig dran vorbei gefahren, habe mich einmal 2 km hinein verfahren auf dem Weg zur Faehre, habe zwei drei mal einen Flieger genommen von und nach London — aber dann immer gleich raus.
Nein, London ist nicht meine Stadt….. Von Reinhard Sternenherz noch in der Rohfassung. Ein weitbekanntes bild, das meiner wahrnehmung nach der allgemeinen wirklichkeit nahe kommt, ist die vorgabe, dass jeder mensch von einem energiefeld umgeben ist. Dieses feld wird von hellsinnigen menschen als aura wahrgenommen. Diese kann gelesen und interpretiert werden, da dieses feld eben die subjektive welt des menschen widerspiegelt. Wie aus medizinischen Unterlagen ersichtlich, hat sie durch ihn in dem Heilzentrum etwa Vitamin C verabreicht bekommen.
Doch sie schafft es nicht. Am August, im Hospiz, will sie ein letztes Mal Sabine Rohwer sehen. Die Bilanz: Reimann hat fast Aber Sabine Rohwer ist mehr als das. Sie hat viele Heiler selbst ausgebildet, ist eine zentrale Figur der Szene. Reimann will Gerechtigkeit. Er sagt, es gehe ihm nicht ums Geld, er wolle, dass Rohwer niemandem mehr schaden kann.
Offizielle Statistiken fehlen. Die Branche will sich selbst regulieren: Der Dachverband der Geistheiler hat sich einen Ethikkodex auferlegt. Reimann wendet sich mit einem Brief an den Verband. Heute braucht er therapeutische Hilfe. Gegen ihn wird zwischenzeitlich ermittelt, er soll einen Schweinskopf auf das Animata-Anwesen gebracht und die Einrichtung mit Blut besudelt haben.
Sabine Rohwer praktiziert immer noch. Weitere auf Anfrage. Der Konzern wurde zu heftigen Geldstrafen und Auflagen verdonnert. Es sind jene Kreise, denen die Siemens Integrity Initiative doch eigentlich das Wasser abgraben wollte. Was ist die IACA? Das zentrale Mittel im Kampf gegen Korruption ist Transparenz. Sie sollen eigentlich die IACA finanzieren. Russland zum Beispiel. Und Aserbaidschan. Wobei: Viel Geld kommt dabei nicht zusammen. Ein Interessenkonflikt.
Andere Teilnehmer des Master-Studiengangs waren entsetzt, als sie sich mit Beamten des Aliyev-Regimes im gleichen Klassenzimmer wiederfanden. Das berichten Augenzeugen. Aus Angst vor Nachstellungen wollte sich niemand namentlich zitieren lassen. Bereits im Jahr kam der Fonds auf die Idee, sich von externen Experten bei der Vorbeugung von Korruption beraten zu lassen.
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Feiner, der heute im Innenministerium arbeitet, reagierte nicht auf eine Anfrage. Pikanter Weise kaufte der Steuerberater einst eine jener Wohnungen, die in den aktuellen Ermittlungen eine Rolle spielen. Die Ermittlungen der Staatsanwaltschaft im Zusammenhang mit dem Fonds richten sich gegen keinen der drei. Nach den ersten Erfahrungen warf am 4. Read die neuesten Pfizer-Zahlen. Rund Millionen Euro habe Pfizer in den ersten drei Monaten damit eingenommen. Es kommt in Frage, wenn einer Frau keine auf Heilung zielende weitere Operation, Strahlentherapie oder Chemotherapie angeboten werden kann.
Eine einzelne Packung mit 21 Tabletten kostet 5. Aufs Jahr gerechnet kostet die Therapie pro Patientin rund Rund Entsprechend hoch sind die Erwartungen vieler Patientinnen an neue Medikamente wie Ibrance. Oktober In der Gruppe, die nur Letrozol erhielt, waren nur 25 von Frauen davon betroffen, wie Kaiser sagt. Auch das hat der G-BA festgelegt.
Einen allzu niedrigen Preis wiederum kann Pfizer kaum akzeptieren. Denkbar ist, dass Pfizer Ibrance in Deutschland komplett vom Markt nimmt. IQWiG Bewertung. Pfizer Analystenkonferenz vom 2. Was steckt hinter Aurum Ventures? Die Staatsanwaltschaft durchleuchtet jetzt die Essener Immobilienfirma.
Dabei handelt es sich um Nickeldraht, gelagert in einem Depot in Magdeburg. Nun ermittelt die Staatsanwaltschaft, ob die Angaben von Aurum Ventures zu dem Nickeldraht zutreffen. Beide Paragrafen stellen es unter Strafe, als Vertreter eines Unternehmens falsche Angaben zu machen. Es ist nicht klar, wer die Seite erstellt hat.
Klingenberg selbst taucht immer wieder in Firmen auf. Ein ungeborenes Kind in der siebten Schwangerschaftswoche. Davon ist nur ein sehr kleiner Teil von einer sogenannten Chromosomen-Anomalie betroffen, zum Beispiel dem Down-Syndrom. Mahnende Stimmen meldeten sich bereits bei der Zulassung des ersten Tests in Deutschland im Jahr Doch erst jetzt gewinnt das Thema an Fahrt. Alles beginnt mit der befruchteten Eizelle, in der die Erbinformation der Mutter und die des Vaters zusammenkommen. Meistens ist ein ganz bestimmtes Chromosom betroffen. Da die Chromosomen nummeriert sind, spricht man von Trisomie 21, 18 oder Das Problem ist aber, dass man diese Anomalien nicht behandeln kann.
Deshalb sind die Untersuchungen auch ethisch umstritten. Und wie geht man mit einem positiven Befund um? Doch alle diese Untersuchungen liefern keinen eindeutigen Befund. Eher selten wird aus der Nabelschnur Blut entnommen. Wissenschaftliche Studien haben gezeigt, dass es bei etwa einer von hundert invasiven Untersuchungen zu einer Fehlgeburt kommt. Allein im vergangenen Jahr gab es in Deutschland Frauen stehen also vor der schweren Entscheidung, ob sie dieses Risiko auf sich nehmen wollen. Auch die Angabe des Geschlechts des Kindes wird teilweise angeboten.
Obwohl die Tests relativ neu sind, gibt es schon eine Menge wissenschaftlicher Untersuchungen. Sie sind also sehr genau.
Es stimmt, dass die Medizin Trisomie an sich nicht behandeln kann. Die schwierige Frage ist, welche Stellung man dem Wohlbefinden der Mutter zuordnet. Ist es fair, dass Schwangeren mit knappen finanziellen Mitteln nur risikoreiche invasive Diagnostik bezahlt wird? Was aber ist eine Risikoschwangerschaft? Der 4. Er schlief noch, als der Angriff auf den Ort begann. Es war wie ein Alptraum. Als gesichert gilt lediglich, dass das Nervengas Sarin eingesetzt wurde. Wenn das Giftgas von der Luft aus eingesetzt wurde, ist dies ein deutlicher Hinweis auf das Assad-Regime. Dieser sei in seiner Zusammensetzung dem Regime zuzuordnen.
Laut Augenzeugen wurde der Angriff auf Khan Scheichun gegen 6. Die syrische Opposition hat Beobachtungsstellen eingerichtet, mit denen sie den Funkverkehr der Luftwaffe Assads verfolgt. April um 6. Vogl, T. Frankfurt Germany ; Boecher, E. Purpose: The purpose of this study was to evaluate local transarterial chemoperfusion TACP in locally recurrent pancreatic carcinoma and advanced tumor stages which did not respond to prior systemic chemotherapy. The tumor response, survival, and pain response were retrospectively analyzed.
Materials and method: Forty outpatients median age 62 years, range 36 - 79 were treated with a minimum of 3 mean 6, range 3 - 12 applications per patient in four-week intervals. Twenty-eight patients were in advanced tumor stages, and 12 patients had locally recurrent tumors. Results: The treatment was tolerated well by all patients. The median survival period since initial diagnosis and first TACP was Locally recurrent tumors showed better, but still not significant results regarding tumor response Radio chemotherapy in locally advanced nonsmall cell lung cancer.
Treatment outcomes have improved over the last decades. Several treatment regimens have been shown effective and safe. This review summarises the results of significant studies between and on concomitant and sequential radiochemotherapy regimens and radiation dose per fraction. Beside therapy regimens, optimised radiotherapy planning is indispensable to improve outcome and minimise radiation-induced toxicity. Simultaneous radiochemotherapy in cervical cancer: recommendations for chemotherapy. Background: Simultaneous radiochemotherapy has recently been demonstrated to be superior to radiation alone in the treatment of cervical cancer.
The objective of this article is to summarize the data of major randomized trials and to derive recommendations for daily clinical practice. Materials and Methods: We have analyzed the data from seven randomized trials in the recent literature in which radiotherapy alone as standard treatment has been compared to simultaneous radiochemotherapy.
Four trials used cisplatin-based chemotherapy regimens, 5-FU, mitomycin C and epirubicin were used each in one trial. Results: All trials demonstrated some improvement in survival which was significant in the studies with cisplatin-based chemotherapy regimens. The survival benefit resulted mainly from an improvement in local control whereas chemotherapy had only a small and insignificant effect on distant metastases. Thus, the main action of chemotherapy is ''radiosensitization''. Cisplatin as single drug yielded comparable results as compared to combined regimens although the cisplatin dose was lower in the studies with combination chemotherapy.
For the definitive treatment of locally advanced cancers, monotherapy with cisplatin can be recommended. Mitomycin C offers an attractive alternative to cisplatin in patients with contraindications for cisplatin. Simultaneous radiochemotherapy should also be considered for the curative treatment of local recurrences. Conclusions: The addition of simultaneous chemotherapy to radiotherapy is indicated in the vast majority of patients with cervical cancers who are treated with curative intent.
Knochenstoffwechsel bei malignen Erkrankungen. Das Gleichgewicht knochenaufbauender wie -abbauender Mechanismen scheint somit durch die Ratio von. Strahlungsfeldbedingungen bei der Ionisationsdosimetrie. Die Bandscheibenprothese bei schmerzhafter Diskusdegeneration. Full Text Available Bandscheibenprothesen sind indiziert bei Patienten mit einer schmerzhaften Bandscheibendegeneration, einer sogenannten DDD degenerative disc disease, bei gut erhaltenen Facettengelenken.
Nachhaltige Komplikationen traten nicht auf. Mehrfacheffekt-Feuchtluftdestillation bei Umgebungsdruck. Ein neuartiges Verfahren zur Feuchtluftdestillation mittels Verdunstung und Kondensation in einer einzigen Kammer wurde im Rahmen der Arbeit umfassend analysiert. Der Transport der im Verdunster beladenen Feuchtluft zum Kondensator erfolgt innerhalb einer optimierten geometrischen Anordnung der Baueinheit Patonay, P. Purpose: to study efficacy and toxicity of radiochemotherapy in esophageal cancer including initial endoluminal high-dose-rate brachytherapy HDR-BT.
Chemotherapy was started simultaneously with external irradiation three courses of cisplatin and 5-fluorouracil, q21d. Median duration of symptomatic improvement was 11 months, median follow-up 12 months range months. Conclusion: these results indicate a favorable effect of simultaneous radiochemotherapy starting with endoluminal HDR-after-loading- AL- BT in esophageal cancer. Increased genitourinary fistula rate after bevacizumab in recurrent cervical cancer patients initially treated with definitive radiochemotherapy and image-guided adaptive brachytherapy. Patients with recurrent cervical cancer RecCC who received definitive radiochemotherapy including image-guided adaptive brachytherapy IGABT as primary treatment are currently treated in our institution with palliative intent by chemotherapy CHT combined with bevacizumab BEV.
Known and presumed risk factors associated with fistula formation were evaluated. Clinical characteristics were comparable. No other risk factors for fistula formation were identified. Future clinical studies are required to identify predictors for fistula formation to subsequently improve patient selection for the addition of BEV in the RecCC setting.
Pre-operative radiochemotherapy of locally advanced rectal cancer. AIM: To evaluate results of pre-operative radiochemotherapy followed by surgery for 15 patients with locally advanced un-resectable rectal cancer. For comparison, 27 similar patients,treated by preoperative radiotherapy Gy plus surgery were served as control RS group. The radical resectability rate was Sphincter preservation rates were Sphincter preservation rates of lower rectal cancer were The tumor downstage rates were 8 The 3-year overall survival rates were The 3-year local recurrent rates were No obvious late effects were found in either groups.
Clinicopathologic study on the effect of preoperative radiochemotherapy for oral squamous cell carcinoma. Preoperative radiochemotherapy has been carried out for many cases of oral cancers to improve locoregional control. The purpose of this study was to evaluate whether preoperative radiochemotherapy for oral squamous cell carcinomas is beneficial for the patients.
A retrospective analysis of patients who had successfully undergone operations at our hospital from April to March was performed. We obtained the following results and conclusions: Preoperative radiochemotherapy for advanced oral squamous cell carcinomas Stage III, IV did not contribute to improvement of the survival rate, although it was effective for locoregional control.
These results indicated that preoperative radiochemotherapy could decrease the reoperations of recurrences and regional lymph node metastases. Therefore, organ preservations were done in some cases by preoperative radiochemotherapy. The preoperative radiochemotherapy effective group showed a better survival rate than the noneffective group, and the response rate of preoperative radiochemotherapy became an independent predictive factor for the prognosis. The cause of death in the noneffective group was mainly local recurrence mostly arising from a deep region of the tumor surgical margin, and Therefore, we should consider setting a larger safety margin especially in the deep region of a tumor that is highly invasive and for which radiochemotherapy is not effective.
Value of magnetic resonance imaging in diffuse liver diseases; Stellenwert der MRT bei diffusen Lebererkrankungen. Schramm, N. T1-gewichtete In- und Opposed-phase-Sequenzen werden im klinischen Alltag am haeufigsten zum Steatosenachweis und zur Fettquantifizierung eingesetzt. Neue Methoden zur Quantifizierung, die nicht durch zahlreiche moegliche Stoerfaktoren wie Eisenueberladung beeinflusst werden, sind in Entwicklung.
Aufgrund der Komplexitaet der Datenakquise und -auswertung sowie der fehlenden Abdeckung der gesamten Leber eignet sie sich noch nicht als Routinemethode. Fruehe Stadien der Leberfibrose koennen mit Standardsequenzen nicht dargestellt werden. Study on effectiveness and tolerance of pre-and postoperative radiochemotherapy for patients with stomach cancer. Postoperative radiochemotherapy was included to the therapeutic scheme of stomach cancer. The effectiveness and tolerance of pre- and postoperative radiochemotherapy were studied.
A Range Scale Risk reflecting the risk of treatment failure , selecting patients with bad prognosis to intensive therapy was established on the base of identified predictive and prognostic factors. The therapeutic schemes with operation followed by adjuvant radiochemotherapy or pre-and postoperative radiochemotherapy were arranged.
The overall survival was better in the second group. Body weight loss, age and performance status of patients, location of tumor, cancer stage evaluation, resected lymph nodes, operation radicality were identified as the independent prognostic factors. In conclusions, combined modality approaches in treatment of stomach cancer were shown as more effective than surgery alone. Neoadjuvant chemotherapy may be more effective than postoperative one.
Postoperative radiochemotherapy started and completed within 5 weeks positively influenced all prognostic factors. Intercalated radio-chemotherapy in small cell lung cancer. A total of 6 cycles of chemotherapy was given. In 15 patients with limited disease intercalated radio-chemotherapy was used in which two 5-day courses of hyperfractionated radiotherapy were given to the thorax after the 1st and 2nd cycles of chemotherapy.
Each course of thoracic radiotherapy delivered 15 Gy in 15 fractions over 5 days. Oesophagitis occurred in 7 patients 40 percent , in 5 of whom this was severe WHO grade 3. Radiological pneumonitis developed in 6 patients 40 percent with subsequent fibrosis in 2 patients. These effects are greater than would be expected with this dose of radiation alone and reflect marked enhancement of normal tissue toxicity.
Postoperative radio-chemotherapy in locally advanced gastric cancer. Adjuvant treatment may improve the surgical results. Aim: To assess treatment results and toxicity in patients with surgically excised gastric cancer, treated with adjuvant radiotherapy and concomitant continuous 5-Fluorouracil 5-FU. Material and Methods: Forty one patients aged 32 to 73 years 29 males with stage II-IVA gastric cancer, subjected to a total or subtotal gastrectomy and D2 nodal dissection between to , were studied.
They received adjuvant radiotherapy to the gastric bed and draining lymphatic nodes in a total dose of Results were compared to historical controls matched according to demographic parameters and tumor characteristics. Twelve patients had an N0 nodal status, 15 were N1, nine were N2 and five were N3. Five year overall survival was Radiotherapy was associated with grade toxicity and treatment was completed without interruptions in all patients.
Chemotherapy was delayed temporarily in 3 patients. Conclusions: Adjuvant radio-chemotherapy improved overall survival in gastric cancer, compared to historical controls subjected only to surgical treatment. Toxicity after radiochemotherapy for glioblastoma using temozolomide - a retrospective evaluation. Retrospective evaluation of toxicity and results after radiochemotherapy for glioblastoma. A total dose of 60 Gy was applied in daily single fractions of 2. The median survival time amounted to Chemotherapy could be completed according to schedule only in Further reasons were an unfavourable general health status or a rise of liver enzymes.
The mean duration of thrombopenia and leucopenia amounted to 64 and 20 days. In two patients, blood cell counts remained abnormal until death. In two patients we noticed a rise of liver enzymes. These values normalized after termination of temozolomide medication. One patient died of pneumonia during therapy. Our survival data were well within the range taken from the literature. However, we noticed a considerable frequency and intensity of side effects to bone marrow and liver. These lead to the recommendations that regular examinations of blood cell count and liver enzymes should be performed during therapy and temozolomide should not be applied or application should be terminated according to the criteria given by the manufacturer.
Treatment results of non-operated lung cancer by radiotherapy and radiochemotherapy. The treatment results of non-operated lung cancer patients were analyzed. The effect of combined radiochemotherapy was quite evident in small cell lung cancer SCLC patients. However, there was considerable case to case variation in the dosage, combination of agents and timing of chemotherapy. Recently, more aggressive chemotherapy is now being applied. The influence of smoking and other risk factors on the outcome after radiochemotherapy for anal cancer.
Smoking is an important risk factor for the development of cancer. Smoking during radiochemotherapy therapy may have a negative influence on prognosis. We evaluated the effect of smoking during radiochemotherapy on the outcome for patients with anal cancer. Sixty-eight patients 34 smokers, 34 non-smokers treated by radiochemotherapy for anal cancer were analysed. The effect of smoking during radiochemotherapy and other risk factors gender, T- and N category, tumor site, dose, therapy protocol on disease-specific survival DSS , local control LC and colostomy free survival CFS was evaluated.
There was a significant difference in age and male:female ratio between the two groups. With a median follow up of 22 months max. The other risk factors did not reach statistical significance. Even though our evaluation reached statistical significance only in univariate analysis, we suggest, that the role of smoking during radiochemotherapy for anal cancer should not be ignored.
The potential negative effect on prognosis should be explained to patients before therapy. Radiochemotherapy of malignant glioma in adults. Clinical experiences. Kortmann, R. Background: Standard treatment in patients with malignant glioma consists of surgery and postoperative radiotherapy. A high early recurrence rate, particularly in glioblastoma, has led to the investigation of additional chemotherapy.
Material and Methods: Recent results of radiochemotherapy published in the literature were reviewed with respect to outcome in phase II and III trials. Based on these experiences, aspects of future strategies were discussed. Results: 3 decades of intensive research had, unfortunately, little impact on the overall results.
While early prospective studies established adjuvant nitrosoureas, particularly BCNU, as suitable adjuvant to surgery and postoperative radiotherapy, further studies largely concentrated on combined chemotherapeutic protocols, mostly procarbazine, CCNU and vincristine PCV , which was shown to prolong survival in anaplastic astrocytoma. Only in high-grade glioma with an oligodendroglial component, additional chemotherapy may be of a decisive benefit.
The introduction of newer drugs such as paclitaxel, temozolomide, or gemcitabine demonstrated no decisive advantage. Different modes of application and sequencing of radiotherapy and chemotherapy are presently actively investigated, but failed to substantially improve outcome. Conclusions: Therefore, search for newer and more effective drugs continues, as well as for ''optimal'' administration and sequencing, especially from the standpoint of accompanying acute and late toxicity.
Finally, recent endeavors focused on basic research such as angiogenesis, migration and invasion, or induction of cell differentiation, but these strategies are still away from broader clinical investigation. Radio-chemotherapy in advanced tumors of the oral cavity, oro- and hypopharynx. Among combined radio-chemotherapy regimens of advanced head and neck tumors four modalities can be discriminated: 1.
Induction chemotherapy, 2. The results of the presently available randomized trials are as follows: 1. Induction chemotherapy has no influence on long-term recurrence-free survival. With respect to simultaneous radio-chemotherapy , recurrence-free survival has been unproved with 5-FU and Mitomycin C. There is evidence that adjuvant cis-platin therapy improves recurrence-free survival. No results are available to date using hyperfractionated accelerated radiotherapy regimens in combination with chemotherapy.
Efficacy and toxicity of postoperative temozolomide radiochemotherapy in malignant glioma. Kocher, M. Purpose: to evaluate the feasibility, safety and efficacy of daily temozolomide concurrent with postoperative radiotherapy in malignant glioma. Median survival was 15 months for glioblastoma.
The combined schedule is effective in oligodendroglioma patients and may prolong survival in glioblastoma. Effort should be taken to minimize corticosteroid doses, since both steroids and temozolomide lead to immunosuppression. Retrospective study about 71 patients with anal carcinoma, treated with a uniform radiochemotherapy ; Retrospektive Studie an 71 Patienten mit Analkarzinom, behandelt mit einheitlicher Radiochemotherapie.
The aim of this retrospectively prospective study was to examine the outcome over all survival, tumorspecific survival, local control, colostomy free survival as well as sideeffects of the tumorspecific treatment on a roughly homogenous and compared to other studies appropriate large group of 71 patients with diagnosed anal carcinoma.
All patients underwent primary radiochemotherapy during the period of to in a municipal hospital. The median follow-up consisted of 38 month. Die Dankesrede bei der Preisverleihung. Obwohl die Dankesrede eine kleinere Randgattung innerhalb des epideiktischen Genres ist, steht sie im Mittelpunkt des Ereignisses. Purpose: To investigate the effect of anemia on outcome of treatment with radiochemotherapy in patients with head-and-neck cancer.
Methods and Materials: The data of patients with Stage II-IV head-and-neck cancer treated with concomitant cisplatin-based radiochemotherapy were retrospectively reviewed. Conclusions: Anemia was strongly associated with local control and survival in this cohort of patients with head-and-neck cancer receiving radiochemotherapy. Chemotherapy or radio-chemotherapy for advanced adenocarcinoma of the oesophagus and cardiac orifice.
They have a high risk to develop lymph nodes metastases and liver metastases. The standard of treatment of these metastatic adenocarcinomas is chemotherapy. Three large randomized comparative studies, between chemotherapy and supportive care, showed that chemotherapy significantly extends the median of survival from months to months and improves the quality of life. Currently, the combination of epirubicin-cisplatin-continuous 5FU ECF is the most effective regimen but it is difficult to administer and tolerate because of the long continuous 5FU infusion.
In France, the most commonly used combination regimen still associates 5FU and cisplatin. New drugs such as docetaxel, CPT11, oxaliplatin used alone or in combination, especially with 5U, are very promising. Radio-chemotherapy is the preferred treatment for locoregional recurrences, because it improves dysphagia and enables to obtain complete tumor responses. Current results from concomitant radio-chemotherapy studies for esophagus cancer, based on 5FU alone, 5FU-cisplatin or 5FU-mitomycin, given as preoperative treatment or as exclusive treatment, support to use radio-chemotherapy for the treatment of loco-regional recurrences after surgical resection.
Nevertheless, the optimal radio-chemotherapy schedule still remain to be defined dose, duration, splitting of radiotherapy, choice of anticancer drugs. Full Text Available Abstract Background Smoking is an important risk factor for the development of cancer. Methods Sixty-eight patients 34 smokers, 34 non-smokers treated by radiochemotherapy for anal cancer were analysed. The effect of smoking during radiochemotherapy and other risk factors gender, T- and N category, tumor site, dose, therapy protocol on disease-specific survival DSS, local control LC and colostomy free survival CFS was evaluated.
Results There was a significant difference in age and male:female ratio between the two groups. Conclusion Even though our evaluation reached statistical significance only in univariate analysis, we suggest, that the role of smoking during radiochemotherapy for anal cancer should not be ignored. Therapienebenwirkungen bei diesem Kollektiv gefunden. Von Patienten, die mit einer primaeren Radiotherapie 62 Patienten oder Radiochemotherapie Patienten behandelt wurden, standen umfassende klinische Daten und Tumormaterial als Paraffinbloecke zur Verfuegung.
Adjuvant versus neoadjuvant radiochemotherapy for locally advanced rectal cancer. Sauer, R. Radiochemotherapy was identical in both arms except for a small-volume boost of 5. Time interval between radiochemotherapy and surgery was weeks in both arms. Techniques of surgery were standardized and included total mesorectal excision. In addition, stratification according to surgeons involved has been provided for. Primary endpoints of the study are 5-year overall-survival, local and distant control, secondary endpoints include rate of curative R0 resections and sphincter saving procedures, toxicity of radiochemotherapy , surgical complications and quality of life.
Results: As of 15th November , patients were randomized from 26 participating institutions: patients were randomized to postoperative radiochemotherapy , patients to preoperative radiochemotherapy. Preliminary results of a randomized trial. Entwicklungstrends bei landwirtschaftlichen Applikationen - ein Zwischenfazit. In diesem Kontext nimmt diese Arbeit eine Bestandsaufnahme und Kategorisierung nativer Applikationen mit landwirtschaftlichem Bezug vor. Planung und Analyse. Outcome and histopathologic regression in oral squamous cell carcinoma after preoperative radiochemotherapy. Background and purpose: preoperative radiochemotherapy has been reported to enhance tumor response and to improve long-term survival in advanced squamous cell carcinoma of the head and neck.
This retrospective study evaluates regression rate and long-term survival in patients with primary oral squamous cell carcinoma treated by neoadjuvant radiochemotherapy and radical surgery. Radical surgery and neck dissection followed after a delay of days. The study only included cases with histologically negative resection margins. Results: after a median follow-up of 5. The median 2-year disease-specific survival DSS rate was Complete histological local tumor regression after surgery ypTO was observed in 50 patients Uni- and multivariate survival analysis revealed that ypT- and ypN-stage were the most decisive predictors for DSS.
This applies especially to cases with complete histological tumor regression after radiochemotherapy , which can be assumed for one of five patients. Retrospective study about 71 patients with anal carcinoma, treated with a uniform radiochemotherapy. Is adjuvant hysterectomy an option after radio-chemotherapy for locally advanced cervical cancer? A review. The purpose of this paper is to review the current concepts in the literature regarding the beneficial effects of adjuvant surgery after concurrent radio-chemotherapy for locally advanced cervical cancer.
Research of the literature was performed using PubMed databases in order to find articles relevant to the central topic. The Marie Curie Foundation in the city of Cordoba in Argentina, has organized the Second Congress of radiochemotherapy and brachytherapy and the Fifth Meeting of Medical Physics in order to collaborate with the scientific growth of radiation oncology and medical physics.
The main topics covered were: patient's radioprotection, brachytherapy with iodine, radiation protection regulatory issues in Argentina, risk analysis in radiotherapy, medical radiation therapy, EPID dosimetry Electronic Portal Image Device , accidents in radiotherapy, among others. The importance of second-look surgery following radio-chemotherapy for advanced ovarian cancer. Fifteen patients with advanced, initially inoperable ovarian cancer stages III and IV were subjected to second-look surgery between May and August following combined radio-chemotherapy.
Each case had shown a distinct reduction in tumour size and a demarcation of the foreign issue, which is considered to be prerequisite for second-look surgery. The diagnostic goal of the operation was to verify the success of the preceding radio-chemotherapeutic treatment by means of exact determination of the extent of the residual tumour. The subsequent therapeutic regimen can, if necessary, be modified accordingly. The therapeutic goal is complete surgical removal of the tumour, if at all possible, since the success of subsequent chemotherapy is dependent on the achievement of this aim.
The mean interval between initial and second-look surgery was three and a half months. Tumour tissue of varying extent was found in 14 out of 15 cases. In 12 cases total extirpation of the internal genitals was successfully carried out, tumour resection was performed twice, and only of third-look surgery, when after two years of radio-chemotherapy and secondary removal of the internal genitals abdominal tumour diagnosis this patient is now undergoing further chemotherapeutic treatment.
We believe that this very case illustrates the importance of second-look surgery and of consistent continuation with radio-chemotherapy in cases of advanced inoperable ovarian cancer. Pilzinfektionen des Zentralnervensystems bei immunkompetentem Wirt. Full Text Available This research aimed to do interpret the marking which flange social criticism and know laboring ideology in story of Comic Strip Pak Bei. Research based on theory of structural semiotic according to Ferdinand De Saussure. Using analysis of Syntagmatic as first level of meaning to the text network and also picture, and analysis of Paradigmatic as second level of meaning or implicit meaning connota-tion, myth, ideology Analysis done to six Comic choice edition of Strip Pak Bei period of November - Februari which tend to flange social criticism.
At band of syntagmatic, result of research indicate that story theme lifted from social problems that happened in major society. The fact clear progressively when connected by Intertextual with information and texts which have preexisted. At band of Paradigmatic, social criticism tend to emerge dimly, is not transparent. Because of Comic Strip Pak Bei expand in the middle of Java cultural domination that developing myth of criticize as action menacing compatibility and orderliness of society.
Story of Comic Strip Pak Bei also confirm dominant ideology in Java society culture, namely ideology of Patriarkhi and Feudalism which still go into effect until now. This prove ideology idea according to Louis Althusser which not again opposition between class, but have been owned and practiced by all social class. Bilateral posterior RION after concomitant radiochemotherapy with temozolomide in a patient with glioblastoma multiforme: a case report.
Radiation induced optic neuropathy RION is a rare but severe consequence of radiation therapy that is associated with adjuvant chemotherapy, specifically therapy with vincristine or nitrosoureas. However, there is very little evidence regarding the occurrence of RION after concomitant radiochemotherapy with temozolomide. The case of a 63 year old woman with glioblastoma multiforme and concomitant radiochemotherapy with temozolomide is described.
Due to a slight depressive episode the patient also took hypericum perforatum. Five months after cessation of fractionated radiation and adjuvant chemotherapy with temozolomide cumulative dose of mg the patient developed bilateral amaurosis due to RION. Tumor regrowth was excluded by magnetic resonance imaging. After the application of gadolinium a pathognomonic contrast enhancement of both prechiasmatic optic nerves could be observed. In this patient, the occurrence of RION may have been the result of radiosensitization by temozolomide, which could have been strengthened by hypericin.
Consequently, physicians should avoid a concomitant application of hypericum perforatum and radiochemotherapy. Pasireotid: Eine neue Therapieoption bei Morbus Cushing. Cytoprotection with amifostine in the simultaneous radio-chemotherapy of recurrent head and neck cancer. Six out of 14 patients got an additional brachytherapy 10 to 15 Gy to increase the local dose because of a residual tumor.
Oral Mucositis is a complex and distinct pathobiologic entity resulting in injuries in mucosa that is a common complication in cancer patients undergoing chemotherapy CT and radiation therapy RT. Phytochemicals, such as Curcumin, turmeric extract, has attracted great attention for its therapeutic benefits in clinical oncology due to its chemopreventive, antitumoral, chemosensibilizing and radiosensibilizing activities against various types of cancers and the complications associated with their management.
To evaluate the efficacy and safety of curcumin mouthwash in the management of Oral Mucositis in cancer patients undergoing radio-chemotherapy.
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The research group consisted of 20 adult cancer patients undergoing radio-chemotherapy at the Regional Oncology Centre, who were evaluated for signs and symptoms of oral mucositis and then randomly divided into two groups. Standard preventive oral care i. Oral mucositis was assessed at days 0, 10 and Adverse events were tracked. Curcumin was found to be better than chlorhexidine mouth wash in terms of rapid wound healing and better patient compliance in management of radio-chemotherapy induced oral mucositis.
No oral or systemic complications were reported. To assess the expression of MVP in cervix carcinoma patients treated by radiochemotherapy , its relation to clinical and pathologic prognostic factors and its role in predicting clinical outcome. In addition the relation to IGF-1R expression in this cohort of patients will be explored.
Sixty consecutive patients suffering from localized cervix carcinoma were prospectively included in this study from July to December Follow-up was closed in November Patients were staged following the TNM classification. All patients received pelvic radiation MVP expression was studied by immunohistochemistry in paraffin-embedded tumour tissue.
MVP was expressed in 58 patients Complete response after treatment was observed in 50 patients Clinical stage of the disease and clinical response to radiochemotherapy were the most important prognostic factors related to survival. MVP and IGF-1R expression were related in clinical cervical tumours and confer reduced long-term local control in patients who achieved clinical complete response to radiochemotherapy. Adjuvant radiochemotherapy in patients with locally advanced high-risk cervical cancer. Heinzelmann, F. Background and purpose: The aim of this retrospective study was to analyze the outcome of patients with locally advanced cervical carcinoma treated by adjuvant radiochemotherapy and to determine risk factors for local and distant relapse.
Furthermore, acute and late effects of treatment were recorded. Patients and methods: A total of 72 patients with FIGO stages I-III cervical carcinoma were treated by radical hysterectomy, pelvic lymphadenectomy, and postoperative radiochemotherapy. Only patients with positive pelvic lymph nodes, parametrial involvement, positive margins, or tumor bulk were eligible. Patients were irradiated with a standard pelvic field The majority of patients received platinum-based chemotherapy. Nine of the 72 patients had pelvic recurrences including only 1 isolated local failure; 23 of the 72 patients presented with distant relapse.
The majority of relapses occurred within the first 3 years after adjuvant treatment. Conclusion: Adjuvant radiochemotherapy in patients with advanced cervical cancer and several risk factors is highly effective to prevent local relapse. Future efforts to improve outcome should be placed on improvement of systemic control especially in subgroups with high-risk features for distant relapse. Combined treatment was well tolerated with moderate acute and late toxicity. Evaluation of the antitumor effect of nimotuzumab combined with radiochemotherapy in treatment of esophageal tumors.
Introduction: esophageal cancer in Cuba is one of the first five causes of death from tumors. The treatment includes chemotherapy, radiotherapy and surgery as well as the discovery of new potential targets for immunotherapy such as the epidermal growth factor receptor. Objective: to evaluate the efficacy and safety of nimotuzumab combined with radiochemotherapy in inoperable esophageal tumors and to compare it with the ordinary treatment given to patients seen at 'Hermanos Ameijeiras' hospital from December to June Method: open, controlled, randomized clinical study was designed for two groups of patients, one with radiochemotherapy plus biotherapy and the other one with radiochemotherapy.
The main variable was the clinical response with which the tumor reduction is classified in accordance with the RECIST criteria: complete remission, partial remission, disease stabilization and progression. Toxicity tests evaluated the adverse events that occurred in patients of each of the groups. Cough, insomnia, gastrointestinal problems and retrosternal pain were frequent in the treatment group whereas the control group suffered gastrointestinal disturbances and asthenia more frequently.
Conclusions: the patients treated with nimotuzumab presented better index of objective response and of disease control and its administration was safe when combined with the set therapy for treatment of inoperable esophageal cancer in line with the Cuban therapeutic standards. Radio chemo therapy of the anal carcinoma. A retrospective study. In a retrospective study the data of a consecutive cohort of patients with a locally advanced squamous cell anal cancer were analysed, who were treated with a radio chemo therapy in the period from to Toxicity and first treatment results after of neoadjuvant thermal radiochemotherapy in operable oesophageal cancer.
Hulshof, M. M; Crezee, J. Full text: To demonstrate the toxicity and preliminary treatment results of neo-adjuvant regional hyperthermia combined with concurrent radiochemotherapy in oesophageal cancer. Background: In a phase I study was completed with neo-adjuvant regional hyperthermia combined with chemotherapy cisplatin and etoposide in patients with operable oesophageal cancer.
It was concluded that hyperthermia was feasible. Based on these results we planned to continue hyperthermia in a phase II study aiming at a decrease of chemotherapy induced toxicity and an improvement of response rate compared to previous radiochemotherapy studies. Chemotherapy was infused during hyperthermia.